TETRASODIUM EDTA (Trilon-B), 39%, L

Parameter	Attribute
Tetrasodium EDTA 39%	N,N′-Ethane-1,2-diylbis[N-(carboxymethyl)glycine], Diaminoethane-tetraacetic acid tetrasodium salt, Edetic acid (conjugate base edetate) full neutralizes with sodium hydroxide, Ethylenedinitrilo-tetraacetic acid tetrasodium salt, Versene, chelate
Formula	C10H16N2O8
Structure
IUPAC	2,2′,2″,2‴-(Ethane-1,2-diyldinitrilo)tetraacetic acid sodium salt
INCI	TETRASODIUM EDTA
CAS	64-02-8
Molar mass	292,244 g/mol
Density	0,860 g/cm3 (at 20 °C)
Solubility	Miscible

Na₄EDTA is the sodium salt of aminopolycarboxylic acid, a colorless water-soluble solid. Its conjugate base is ethylenediaminetetraacetate. It is widely used for the dissolution of limestone or lime precipitates and the formation of chelating compounds.

In the food industry, EDTA is added to some foods as a preservative or stabilizer to prevent catalytic oxidation, which causes discoloration. In soft drinks containing ascorbic acid and sodium benzoate, EDTA reduces the formation of benzene (carcinogen).

In agriculture and horticulture, EDTA can be used to dissolve various metal ions at neutral or lower pH, thus facilitating the uptake of trace elements by plants. The use of EDTA in fertilizer applications reduces the amount of fertilizer used to achieve the same effect. The metal ions bound by EDTA become unaffected by other substances in the environment, such as the fertilizer. Calcium does not react with the carbonate ion resulting in insoluble calcium carbonate, iron does not react with phosphates resulting in insoluble iron phosphate.

In metalworking, Na₄EDTA is mainly used to remove metal ions from aqueous solutions. It is particularly useful for mild cleaning of the metal surface and to prevent surface damage (which occurs when cleaning plaque with strong mineral acids). Sodium EDTA binds the metal ions in the form of salts (in the form of plaque), thus dissolving them, but does not dissolve the metal itself, since the pH is alkaline, i.e. slowing down the corrosive effect of the metal.

In the water treatment industry, it reduces the hardness of water and facilitates the removal of deposits in water heaters (boilers). This chelate can be found in most descaling agents. In detergents, EDTA softens water by binding metal ions and increases the effect of surfactants.

In medicine, a special salt of EDTA, known as sodium calcium edetate, is used to bind metal ions during chelation therapy, for example in the treatment of mercury and lead poisoning. Similarly, it is used to remove excess iron from the body. This therapy is used to treat the complication of repeated blood transfusions and can also be used to treat thalassaemia. Dentists and endodontists use EDTA solutions to remove inorganic debris and lubricate root canals. In addition, EDTA solutions containing a surfactant loosen calcification in root canals and allow the canals to form. It is used as a preservative (usually increasing the effect of other preservatives such as benzalkonium chloride or thiomersal) in eye preparations and eye drops. EDTA is widely used in blood analysis. It is an anticoagulant for CBC/FBE blood samples, where EDTA chelates the calcium in the blood sample, stops the clotting process and preserves the morphology of blood cells. EDTA is a fluid dispersant and has been found to be a very effective agent in reducing bacterial growth in intraocular lens implantation.

In cosmetics, EDTA salts are used as a sequestering agent in shampoos, cleansers and other personal care products to improve their stability in air, and to improve the performance of cosmetic products when used in hard water. Tetrasodium EDTA binds calcium, magnesium and other metal ions, so that cosmetic products with PAMAM foam better and require less product to achieve the desired effect. INCI feature:

• Chelating: Reacts and forms complexes with metal ions which may affect the stability and/or appearance of cosmetic products.

In laboratories EDTA is widely used to extract metal ions. In biochemistry and molecular biology, ion depletion is a commonly used method to deactivate metal-dependent enzymes, as an assay for their reactivity or to inhibit damage to DNA, proteins or polysaccharides. In analytical chemistry, EDTA is used for complexometric titration and water hardness analyses, or as a layering agent to remove metal ions that would interfere with the analysis. It is used in the cement industry to determine the free calcium oxide and magnesium content of cement and clinker. Used for the separation of lanthanide metals (lanthanides) in ion-exchange chromatography.

In the textile industry, it prevents metal ions from adjusting (changing) the colour of dyed products.

In the paper industry, EDTA inhibits the ability of metal ions, especially Mn2+, to catalyse the disproportionation of hydrogen peroxide, which is used for chlorine-free bleaching.

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